Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which affects about
0.5–1% of people with symptoms that significantly impact a sufferer's lifestyle. The cells …

Background and Purpose Celastrol exhibits anti‐arthritic effects in rheumatoid arthritis (RA),
but the role of celastrol‐mediated Ca2+ mobilization in treatment of RA remains undefined …

Introduction: Psoriasis is an inflammatory autoimmune skin disease that is hard to cure and
prone to relapse. Currently available global immunosuppressive agents for psoriasis may …

Aim Cholangiocarcinoma is a malignant tumor originating from bile duct epithelium.
Currently, the treatment strategy is very limited and the prognosis is poor. Recent studies …

Sepsis is currently the main factor of death in the ICU, and the liver, as an important organ of
immunity and stable metabolism, can be acutely damaged during sepsis, and the mortality …

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family
(CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is …

Since its medical legalization, cannabis preparations containing the major
phytocannabinoids (cannabidiol (CBD) and δ9-tetrahydrocannabinol (THC)) have been …

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic
exposure to cigarette smoke (CS). Celastrol is a pentacyclic triterpenoid compound exhibits …

Inflammation can be triggered by any factor. The primary pathological manifestations can be
summarized as the deterioration, exudation, and proliferation of local tissues, which can …