The chemical biology of naphthoquinones and its environmental implications

Y Kumagai, Y Shinkai, T Miura… - Annual review of …, 2012 - annualreviews.org
Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

Cellular responses to nanoparticles: target structures and mechanisms

K Unfried, C Albrecht, LO Klotz, A Von Mikecz… - …, 2007 - Taylor & Francis
Nanotechnology makes use of the special surface properties of extremely small particles. In
this rapidly growing field, many different materials are produced for a multitude of diverse …

Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas

P Peruzzi, C Dominas, G Fell, JD Bernstock… - Science translational …, 2023 - science.org
The lack of reliable predictive biomarkers to guide effective therapy is a major obstacle to the
advancement of therapy for high-grade gliomas, particularly glioblastoma (GBM), one of the …

1, 4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling

LO Klotz, X Hou, C Jacob - Molecules, 2014 - mdpi.com
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …

Interactions of nanoparticles with pulmonary structures and cellular responses

C Muhlfeld, B Rothen-Rutishauser… - … of Physiology-Lung …, 2008 - journals.physiology.org
Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable
interest among pulmonary researchers and clinicians for two main reasons. 1) Inhalation …

Learning drug functions from chemical structures with convolutional neural networks and random forests

JG Meyer, S Liu, IJ Miller, JJ Coon… - Journal of chemical …, 2019 - ACS Publications
Empirical testing of chemicals for drug efficacy costs many billions of dollars every year. The
ability to predict the action of molecules in silico would greatly increase the speed and …

Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis

MM Cortese, CV Suschek, W Wetzel… - Free Radical Biology …, 2008 - Elsevier
Oxidative stress is one of the main causes of vascular disease. This study aims to investigate
the antioxidant activity exerted by zinc in primary rat endothelial cells (EC). Using a 24-h …

1, 4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes

V Klaus, T Hartmann, J Gambini, P Graf, W Stahl… - Archives of biochemistry …, 2010 - Elsevier
Selected biological effects of 1, 4-naphthoquinone, menadione (2-methyl-1, 4-
naphthoquinone) and structurally related quinones from natural sources–the 5-hydroxy …

[HTML][HTML] Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?

A Salameh, S Dhein - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …

In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells

H Gehrke, A Frühmesser, J Pelka, M Esselen… - …, 2013 - Taylor & Francis
The use of nanostructured silica (SiO2) particles is no longer restricted to biomedical and
(bio-) technological fields but rather finding applications in products of the food industry …