Cancer of unknown primary: challenges and progress in clinical management
N Laprovitera, M Riefolo, E Ambrosini, C Klec… - Cancers, 2021 - mdpi.com
Simple Summary Patients with cancer of unknown primary site suffer the burden of an
uncertain disease, which is characterized by the impossibility to identify the tissue where the …
uncertain disease, which is characterized by the impossibility to identify the tissue where the …
International consensus on the initial diagnostic workup of cancer of unknown primary
I van der Strate, F Kazemzadeh, ID Nagtegaal… - Critical Reviews in …, 2023 - Elsevier
Background Although the incidence of Cancer of Unknown Primary (CUP) is estimated to be
1–2% of all cancers worldwide, no international standards for diagnostic workup are yet …
1–2% of all cancers worldwide, no international standards for diagnostic workup are yet …
[HTML][HTML] Molecular profiling of driver events in metastatic uveal melanoma
Metastatic uveal melanoma is less well understood than its primary counterpart, has a
distinct biology compared to skin melanoma, and lacks effective treatments. Here we …
distinct biology compared to skin melanoma, and lacks effective treatments. Here we …
Treatment with anti-HER2 chimeric antigen receptor tumor-infiltrating lymphocytes (CAR-TILs) is safe and associated with antitumor efficacy in mice and companion …
Simple Summary CAR-T cells are immune cells equipped with a claw that enable them to
bind cancer cells. Usually, CAR-T cells are made using immune cells from blood. Here, we …
bind cancer cells. Usually, CAR-T cells are made using immune cells from blood. Here, we …
[HTML][HTML] Development and clinical validation of a 90-gene expression assay for identifying tumor tissue origin
Q Ye, Q Wang, P Qi, J Chen, Y Sun, S Jin… - The Journal of Molecular …, 2020 - Elsevier
The accurate identification of tissue origin in patients with metastatic cancer is critical for
effective treatment selection but remains a challenge. The aim of this study is to develop a …
effective treatment selection but remains a challenge. The aim of this study is to develop a …
Machine learning for pan-cancer classification based on RNA sequencing data
Despite recent improvements in cancer diagnostics, 2%-5% of all malignancies are still
cancers of unknown primary (CUP), for which the tissue-of-origin (TOO) cannot be …
cancers of unknown primary (CUP), for which the tissue-of-origin (TOO) cannot be …
Immunochemotherapy achieved a complete response for metastatic adenocarcinoma of unknown primary based on gene expression profiling: a case report and …
J Sheng, H Pan, W Han - Frontiers in Immunology, 2023 - frontiersin.org
Background Cancer of unknown primary (CUP) is a malignant and aggressive tumor whose
primary origin is still unknown despite thorough evaluation. CUP can be life-threatening with …
primary origin is still unknown despite thorough evaluation. CUP can be life-threatening with …
[HTML][HTML] Genetics and Therapeutic Responses to Tumor-Infiltrating Lymphocyte Therapy of Pancreatic Cancer Patient-Derived Xenograft Models
Background and Aims Pancreatic cancer is the seventh leading cause of cancer-related
deaths worldwide. Checkpoint immunotherapy has not yet shown encouraging results in …
deaths worldwide. Checkpoint immunotherapy has not yet shown encouraging results in …
H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines
To the Editor—We read with great interest the recent paper1 by Alvarez et al. In it, they use
the VIPER algorithm2 to mine transcriptome data from 212 rare gastroentero-pancreatic …
the VIPER algorithm2 to mine transcriptome data from 212 rare gastroentero-pancreatic …
Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanoma
J Karlsson, LM Nilsson, EMV Forsberg, S Mitra, S Alsén… - bioRxiv, 2019 - biorxiv.org
Uveal melanoma (UM) is a rare form of melanoma with a genetics and immunology that is
different from skin melanoma. Previous studies have identified genetic driver events of early …
different from skin melanoma. Previous studies have identified genetic driver events of early …