Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved
regulators of eukaryotic cell function. These enzymes regulate many biological processes …

Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of
signaling pathways, and there is mounting evidence that they have frequently retained the …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

Proteomic analysis of the human body is a significant recent scientific endeavour. In this
study, we investigated the proteomic profile of human dentin using modern analytical and …

We investigated transcriptomic markers of late-onset major depressive disorder (LOD; onset
age of first depressive episode≥ 50 years) from the genes expressed in blood cells and …

Phosphatases are a diverse family of enzymes, comprising at least 10 distinct protein folds.
Like most other enzyme families, many have sequence variations that predict an impairment …

Significance: Apoptosis is a complex cellular process subject to multiple layers of regulation.
One such layer of regulation includes post-translational modifications, including acetylation …

The pseudophosphatases, atypical members of the protein tyrosine phosphatase family,
have emerged as bona fide signaling regulators within the past two decades. Their roles as …

Mitogen activated protein kinase phosphoserine/threonine/tyrosine-binding protein (MK-
STYX) is a dual specificity (DUSP) member of the protein tyrosine phosphatase family. It is a …

Pseudophosphatases are atypical members of the protein tyrosine phosphatase
superfamily. Mutations within their catalytic signature motif render them catalytically inactive …