Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy

ER Lumbers, KG Pringle - American Journal of Physiology …, 2014 - journals.physiology.org
This review describes the changes that occur in circulating renin-angiotensin-aldosterone
system (RAAS) components in human pregnancy. These changes depend on endocrine …

Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia

ER Lumbers, SJ Delforce, AL Arthurs… - Frontiers in …, 2019 - frontiersin.org
A healthy pregnancy outcome depends on the activation of the renin-angiotensin-
aldosterone system (RAAS) as a regulated, integrated response to the growing demands of …

The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: key agents for treatment

ER Lumbers, R Head, GR Smith… - Pharmacology …, 2022 - Wiley Online Library
SARS‐CoV‐2 interacting with its receptor, angiotensin‐converting enzyme 2 (ACE2), turns
the host response to viral infection into a dysregulated uncontrolled inflammatory response …

The biochemistry of the renin-angiotensin system and its role in hypertension

LT Skeggs, FE Dorer, JR Kahn, KE Lentz… - The American journal of …, 1976 - Elsevier
The renin-angiotensin system has an important role in maintaining elevated blood pressure
levels in certain forms of experimental and human hypertension. Renin, an enzyme …

Angiotensin and aldosterone

ER Lumbers - Regulatory peptides, 1999 - Elsevier
The object of this review is to describe the role of the renin–angiotensin system in control of
aldosterone secretion. The review focuses on the roles of the circulating renin–angiotensin …

Prorenin and other large molecular weight forms of renin

JE Sealey, SA Atlas, JH Laragh - Endocrine Reviews, 1980 - academic.oup.com
The physiological role of plasma prorenin remains to be defined, and its extrarenal sources
are yet to be identified. A prorenin-like substance is present in high concentrations in …

Angiotensins I and II, active and inactive renin, renin substrate, renin activity, and angiotensinase in human liquor amnii and plasma

SL Skinner, EJ Cran, R Gibson, R Taylor… - American Journal of …, 1975 - Elsevier
Most of the renin in liquor amnii and plasma exists in an inactive form which can be activated
by acidification to pH 3.3. In liquor collected by paracentesis at 34 to 37 weeks' gestation, 83 …

Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin

JE Sealey, SA Atlas, JH Laragh, NB OZA, JW RYAN - Nature, 1978 - nature.com
WE have found that human urinary kallikrein converts inactive plasma renin in vitro to an
enzyme with renin-like activity. This observation is interesting because renal kallikrein, the …

Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor

JJ Panthier, S Foote, B Chambraud, AD Strosberg… - Nature, 1982 - nature.com
Renin, a protease which cleaves the prohormone angiotensinogen, releasing angiotensin I,
has a major role in regulating blood pressure and electrolyte balance. However, the primary …

Iso-renin of extrarenal origin: The tissue angiotensinogenase systems

D Ganten, P Schelling, P Vecsei, U Ganten - The American Journal of …, 1976 - Elsevier
Enzymes, similar to kidney renin, are present in extrarenal tissue of most mammals; they
hydrolyze angiotensinogen to form angiotensin I. We suggest that these enzymes be called …