The aging process is a multifactorial biological phenomenon starting at birth and persisting
throughout life, characterized by a decline in physiological functions and adaptability. This …

Canine cognitive dysfunction (CCD) is a form of dementia that shares many similarities with
Alzheimer's disease. Given that physical activity is believed to reduce risk of Alzheimer's …

Circadian biology's impact on human physical health and its role in disease development
and progression is widely recognized. The forefront of circadian rhythm research now …

Background The veterinary care of cats and dogs is increasingly embracing innovations first
applied to human health, including an increased emphasis on preventative care and …

Dogs have a special place in human history as the first domesticated species and play
important roles in many cultures around the world. However, their role in scientific studies …

Cardiovascular and cerebrovascular diseases are the most common cause of death among
older people in the United States, accounting for∼ 1/3 of all deaths in the US at the age of …

The brain, as the most metabolically active organ in the human body, consumes
approximately 20% of the body's energy supply at rest. This high energy demand is fulfilled …

Osteoarthritis (OA) is one of the most prevalent age-related chronic conditions that afflict
companion dogs, and multiple joint supplements are available to prevent or treat OA, though …

Exposure to social environmental adversity is associated with health and survival across
many social species, including humans. However, little is known about how these health …

The loss of energy homeostasis seen during aging, is causally linked to multiple age-related
pathologies. The AMP-activated protein kinase (AMPK) directly senses cellular energy …