PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been
demonstrated as an important regulator in diverse human cancers. However, its function and …

The brain endothelium is an important therapeutic target for the inhibition of cerebrovascular
dysfunction in ischemic stroke. Previously, we documented the important regulatory roles of …

Mild traumatic brain injury (mTBI) results from a transfer of mechanical energy into the brain
from traumatic events such as rapid acceleration/deceleration, a direct impact to the head, or …

The importance of various classes of regulatory non-protein-coding RNA molecules
(ncRNAs) in the normal functioning of the CNS is becoming increasingly evident. ncRNAs …

Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …

Circular RNAs (circRNAs) are a type of non-coding RNAs (ncRNAs), produced in eukaryotic
cells during post-transcriptional processes. They are more stable than linear RNAs, and …

Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in
the mammalian brain. While the protein machinery has remained largely constant …

Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of
its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA …