The innate immune system is central for the maintenance of tissue homeostasis and quickly
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …

Tolerogenic dendritic cells (tDC) are a promising tool for specific cellular therapy to induce
immunological tolerance in transplantation and autoimmunity. To date, most described tDC …

The ability of dendritic cells (DC) to regulate Ag-specific immune responses via their
influence on T regulatory cells (Treg) may be key to their potential as therapeutic tools or …

The mammalian target of rapamycin (mTOR) regulates cell growth and survival and exists as
rapamycin-sensitive mTOR complex (mTORC) 1 and as rapamycin-insensitive mTORC2 …

Plasticity is a hallmark of macrophages, and in response to environmental signals these
cells undergo different forms of polarized activation, the extremes of which are called classic …

The pursuit of clinical transplant tolerance has led to enhanced understanding of
mechanisms underlying immune regulation, including the characterization of immune …

Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to
self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic …

Aging is a physiologic/pathologic process characterized by a progressive impairment of
cellular functions, supported by the alterations of several molecular pathways, leading to an …

Over the last decades, our understanding of adaptive immune responses to solid organ
transplantation increased considerably and allowed development of immunosuppressive …