Thermal ablation of tumours: biological mechanisms and advances in therapy

KF Chu, DE Dupuy - Nature Reviews Cancer, 2014 - nature.com
Minimally invasive thermal ablation of tumours has become common since the advent of
modern imaging. From the ablation of small, unresectable tumours to experimental …

Cancer vaccines

LH Butterfield - Bmj, 2015 - bmj.com
Cancer vaccines are designed to promote tumor specific immune responses, particularly
cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines …

More than just tumor destruction: immunomodulation by thermal ablation of cancer

SP Haen, PL Pereira, HR Salih… - Journal of …, 2011 - Wiley Online Library
Over the past decades, thermoablative techniques for the therapy of localized tumors have
gained importance in the treatment of patients not eligible for surgical resection. Anecdotal …

Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases

W Rule, R Timmerman, L Tong, R Abdulrahman… - Annals of surgical …, 2011 - Springer
Purpose To identify a tolerable and effective dose for 5-fraction stereotactic body
radiotherapy for hepatic metastases. Methods Patients were enrolled onto three dose …

Radiofrequency thermal ablation for hepatocellular carcinoma stimulates autologous NK-cell response

A Zerbini, M Pilli, D Laccabue, G Pelosi, A Molinari… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Radiofrequency thermal ablation (RFA) is a minimally invasive
technique used as standard local therapy of hepatocellular carcinoma and second-line …

Irreversible electroporation induces CD8+ T cell immune response against post-ablation hepatocellular carcinoma growth

Z Dai, Z Wang, K Lei, J Liao, Z Peng, M Lin, P Liang… - Cancer Letters, 2021 - Elsevier
Ablative treatment evokes antitumor immunity, but knowledge on the emerging irreversible
electroporation (IRE)-induced immunity in hepatocellular carcinoma (HCC) is limited. To …

Irreversible electroporation versus radiofrequency ablation: a comparison of local and systemic effects in a small-animal model

BE Bulvik, N Rozenblum, S Gourevich, M Ahmed… - Radiology, 2016 - pubs.rsna.org
Purpose To compare both periablational and systemic effects of two mechanistically different
types of ablation: thermal radiofrequency (RF) ablation and electroporative ablation with …

The synergistic effect of interventional locoregional treatments and immunotherapy for the treatment of hepatocellular carcinoma

N Brandi, M Renzulli - International Journal of Molecular Sciences, 2023 - mdpi.com
Immunotherapy has remarkably revolutionized the management of advanced HCC and
prompted clinical trials, with therapeutic agents being used to selectively target immune cells …

Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer

G Mauri, L Nicosia, Z Xu, S Di Pietro… - The British journal of …, 2018 - academic.oup.com
Various kinds of image-guided techniques have been successfully applied in the last years
for the treatment of tumours, as alternative to surgical resection. High intensity focused …

Injectable immunotherapeutic thermogel for enhanced immunotherapy post tumor radiofrequency ablation

M Chen, Y Tan, J Hu, Y Jiang, Z Wang, Z Liu, Q Chen - Small, 2021 - Wiley Online Library
Tumor radiofrequency ablation (RFA) is a local and minimally invasive application using
high temperature to induce coagulative necrosis of tumor, which has been commonly used …