Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Autophagy can be dynamically induced in response to stresses and is an essential,
ubiquitous intracellular recycling system that impacts the fate of damaged resident cells …

Osteoporosis (OP) is a disease affecting the elderly and is characterized by incremental
fractures and bone fragility. Small extracellular vesicles (sEVs) derived from mesenchymal …

Introduction Bone marrow‐derived mesenchymal stem cells (BMSCs)‐derived exosomes
are involved in the modulation of tissue repair and regeneration. CircRNAs play important …

Objective Resveratrol is a natural polyphenolic compound that ameliorates postmenopausal
osteoporosis by activating the estrogen receptor. Research has shown that resveratrol …

In recent decades, many studies using the zebrafish model organism have been performed.
Zebrafish, providing genetic mutants and reporter transgenic lines, enable a great number of …

Abstract Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in
either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy'–GACI) …

Musculoskeletal injuries are common in humans. The cascade of cellular and molecular
events following such injuries results either in healing with functional recovery or scar …

Primary cilia are microtubule-based organelles protruding from the surface of almost all
vertebrate cells. This organelle represents the cell's antenna which acts as a communication …