Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular
communication in the nervous system and are involved in fundamental processes such as …

The nicotinic acetylcholine (ACh) receptor, at the neuromuscular junction, is a
neurotransmitter-gated ion channel that has been fine-tuned through evolution to transduce …

Pentameric ligand-gated ion channels mediate fast chemical transmission of nerve signals.
The structure of a bacterial proton-gated homolog has been established in its open and …

© 2013 Hoshi and Armstrong This article is distributed under the terms of an Attribution–
Noncommercial–Share Alike–No Mirror Sites license for the first six months after the …

The concept of allosteric interaction was initially proposed to account for the inhibitory
feedback mechanism mediated by bacterial regulatory enzymes. In contrast with the …

Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic communication by
converting chemical signals into an electrical response. Recently solved agonist-bound and …

Although it has long been proposed that membrane proteins may contain tightly bound
lipids, their identity, the structure of their binding sites, and their functional and structural …

Desensitization in pentameric ligand-gated ion channels plays an important role in
regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω …

Membrane lipids are potent modulators of the nicotinic acetylcholine receptor (nAChR) from
Torpedo. Lipids influence nAChR function by both conformational selection and kinetic …

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but a
structural understanding of anesthetic action on pLGICs remains elusive. GLIC, a prokaryotic …