Athletes are continually seeking new technologies and therapies to gain a competitive edge
to maximize their health and performance. Athletes have gravitated toward the use of …

The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

Orexins are produced specifically by neurons located in the lateral hypothalamus. Recent
results suggested peripheral actions of orexins. Therefore, we analyzed the mRNA …

The pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN) are still poorly
understood, but psychobiological models have proposed a key role for disturbances in the …

Orexin A (OXA) and orexin B were originally isolated as hypothalamic peptides regulating
sleep, wakefulness and feeding. However, growing evidence suggests that orexins have …

Orexin-A is a neuropeptide present in the brain and is known to regulate feeding and
sleeping. In this study, we examined the systemic distribution of orexin-A in human tissues …

Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …

A single dose of the orexin-1 (OX1) receptor antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1, 5]
naphthyridin-4-yl urea hydrochloride (SB-334867-A) reduces orexin-A-induced feeding and …

At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-
B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …