TFOS DEWS II pain and sensation report
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
Neurotrophic keratopathy
HS Dua, DG Said, EM Messmer, M Rolando… - Progress in retinal and …, 2018 - Elsevier
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …
In vivo confocal microscopy of corneal nerves in health and disease
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
Corneal nerves in health and disease
MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …
maintain transparency and contribute to corneal health by mediating tear secretion and …
Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura
Attacks of migraine with aura represent a phenomenon in which abnormal neuronal activity
in the cortex produces sensory disturbances (aura) some 20–40 min before the onset of …
in the cortex produces sensory disturbances (aura) some 20–40 min before the onset of …
Neural basis of sensation in intact and injured corneas
C Belmonte, MC Acosta, J Gallar - Experimental eye research, 2004 - Elsevier
A renewed interest in the characteristics and neural basis of corneal and conjunctival
sensations is developing in recent years due to the high incidence of discomfort and altered …
sensations is developing in recent years due to the high incidence of discomfort and altered …
What causes eye pain?
C Belmonte, MC Acosta, J Merayo-Lloves… - Current ophthalmology …, 2015 - Springer
Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …
discriminative, emotional, cognitive, and behavioral components and supported by distinct …
[HTML][HTML] Morphological and functional changes of corneal nerves and their contribution to peripheral and central sensory abnormalities
A Guerrero-Moreno, C Baudouin… - Frontiers in cellular …, 2020 - frontiersin.org
The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …
Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat
A Malick, RM Strassman… - Journal of …, 2000 - journals.physiology.org
Sensory information that arises in orofacial organs facilitates exploratory, ingestive, and
defensive behaviors that are essential to overall fitness and survival. Because the …
defensive behaviors that are essential to overall fitness and survival. Because the …
Specificity of cold thermotransduction is determined by differential ionic channel expression
Sensations of cold are mediated by specific thermoreceptor nerve endings excited by low
temperature and menthol. Here we identify a population of cold-sensitive cultured mouse …
temperature and menthol. Here we identify a population of cold-sensitive cultured mouse …