Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and
RNA G‐rich sequences are capable of forming a four‐stranded structure, known as the G …

Abstract 2D nanomaterials have attracted considerable research interest in drug delivery
systems, owing to their intriguing quantum size and surface effect. Herein, Gd3+‐doped …

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes.
Such structures have gained significant interest in the past decade with increasing evidence …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

Repeated guanine tracts in human and other genomes can form higher-order four stranded
structures, termed quadruplexes. In the human genome they have particular prevalence in …

The G-quadruplex ligands database (G4LDB, http://www. g4ldb. org) provides a unique
collection of reported G-quadruplex ligands to streamline ligand/drug discovery targeting G …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

G‐Quadruplexes are distinct nucleic acid secondary structures that are formed from G‐rich
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …