Exploring genetic interactions and networks with yeast

C Boone, H Bussey, BJ Andrews - Nature Reviews Genetics, 2007 - nature.com
The development and application of genetic tools and resources has enabled a partial
genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis …

Getting connected: analysis and principles of biological networks

X Zhu, M Gerstein, M Snyder - Genes & development, 2007 - genesdev.cshlp.org
The execution of complex biological processes requires the precise interaction and
regulation of thousands of molecules. Systematic approaches to study large numbers of …

Computed structures of core eukaryotic protein complexes

IR Humphreys, J Pei, M Baek, A Krishnakumar… - Science, 2021 - science.org
INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …

The BioGRID interaction database: 2017 update

A Chatr-Aryamontri, R Oughtred, L Boucher… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the annotation and archival …

A multidimensional systems biology analysis of cellular senescence in aging and disease

RA Avelar, JG Ortega, R Tacutu, EJ Tyler, D Bennett… - Genome biology, 2020 - Springer
Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …

The BioGRID interaction database: 2015 update

A Chatr-Aryamontri, BJ Breitkreutz… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …

Structure-based prediction of protein–protein interactions on a genome-wide scale

QC Zhang, D Petrey, L Deng, L Qiang, Y Shi, CA Thu… - Nature, 2012 - nature.com
The genome-wide identification of pairs of interacting proteins is an important step in the
elucidation of cell regulatory mechanisms,. Much of our present knowledge derives from …

A survey of statistical network models

A Goldenberg, AX Zheng, SE Fienberg… - … and Trends® in …, 2010 - nowpublishers.com
Networks are ubiquitous in science and have become a focal point for discussion in
everyday life. Formal statistical models for the analysis of network data have emerged as a …

High-quality binary protein interaction map of the yeast interactome network

H Yu, P Braun, MA Yıldırım, I Lemmens, K Venkatesan… - Science, 2008 - science.org
Current yeast interactome network maps contain several hundred molecular complexes with
limited and somewhat controversial representation of direct binary interactions. We carried …