New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity
LZ Chen, WW Sun, L Bo, JQ Wang, C Xiu… - European Journal of …, 2017 - Elsevier
To develop new anti-inflammatory agents with improved pharmaceutical profiles, a series of
new phenyl-pyrazoline-coumarin derivatives (4a∼ 4m) were designed and synthesized …
new phenyl-pyrazoline-coumarin derivatives (4a∼ 4m) were designed and synthesized …
Development of pyrazole derivatives in the management of inflammation
LC Turones, AN Martins, LKS Moreira… - Fundamental & …, 2021 - Wiley Online Library
The therapeutic limitations and poor management of inflammatory conditions are anticipated
to impact patients negatively over the coming decades. Following the synthesis of the first …
to impact patients negatively over the coming decades. Following the synthesis of the first …
Pharmacological activity of 4, 5-dihydropyrazole derivatives
DD Korablina, NI Vorozhtsov, LA Sviridova… - Pharmaceutical …, 2016 - Springer
Pharmacological Activity of 4,5-Dihydropyrazole Derivatives (Review) | SpringerLink Skip to
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[HTML][HTML] Optimization of pyrazolo [1, 5-a] pyrimidine based compounds with pyridine scaffold: Synthesis, biological evaluation and molecular modeling study
Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
Non-acidic 1, 3, 4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile
Abstract Twelve new compounds of 1, 3, 4-trisubstituted-pyrazole derivatives possessing
two cyclooxygenase-2 (COX-2) pharmacophoric moieties (SO 2 Me or/and SO 2 NH 2) 11a …
two cyclooxygenase-2 (COX-2) pharmacophoric moieties (SO 2 Me or/and SO 2 NH 2) 11a …
Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation
N Razzaghi-Asl, S Mirzayi, K Mahnam… - Journal of Molecular …, 2018 - Elsevier
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy
was performed on a series of compounds. For this purpose, ZINC database was screened …
was performed on a series of compounds. For this purpose, ZINC database was screened …
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: determination of regio-specific different pyrazole cyclization by …
EKA Abdelall, GM Kamel - European Journal of Medicinal Chemistry, 2016 - Elsevier
Abstract Two new series of 1, 5-diaryl pyrazoles (5a, 5b, 7a, 7b and 10) and 1, 5-diaryl
pyrazoline (12a and 12b) were prepared as both Cyclooxygenase-2 and 15-lipoxygenase …
pyrazoline (12a and 12b) were prepared as both Cyclooxygenase-2 and 15-lipoxygenase …
Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular …
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-
carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro …
carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro …
Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: anti-inflammatory activity, histopatholgical profile and in-silico studies
A novel series of halogenated triarylpyrazoles 12a-l was designed and synthesized. All
target compounds showed good in vitro COX-2 inhibitory activity (IC 50= 0.043–0.17 µM) …
target compounds showed good in vitro COX-2 inhibitory activity (IC 50= 0.043–0.17 µM) …
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific …
EKA Abdelall, PF Lamie, WAM Ali - Bioorganic & medicinal chemistry …, 2016 - Elsevier
Abstract Two new series of 1, 5-diaryl pyrazoline (3a–f) and 1, 5-diaryl pyrazole (5a and 5b)
were designed as both COX-2 and 15-LOX inhibitors. All the prepared compounds were …
were designed as both COX-2 and 15-LOX inhibitors. All the prepared compounds were …