Cholinesterases and the fine line between poison and remedy
CN Pope, S Brimijoin - Biochemical pharmacology, 2018 - Elsevier
Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …
1.8) are related enzymes found across the animal kingdom. The critical role of …
[HTML][HTML] A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
The multiple biological roles of the cholinesterases
I Silman - Progress in biophysics and molecular biology, 2021 - Elsevier
It is tacitly assumed that the biological role of acetylcholinesterase is termination of synaptic
transmission at cholinergic synapses. However, together with its structural homolog …
transmission at cholinergic synapses. However, together with its structural homolog …
[HTML][HTML] Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor …
KE Larrimore, IC Kazan, L Kannan, RP Kendle… - Scientific reports, 2017 - nature.com
Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and
may function as a generalized bioscavenger by binding and/or hydrolyzing various …
may function as a generalized bioscavenger by binding and/or hydrolyzing various …
[HTML][HTML] In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression
Human butyrylcholinesterase (BChE) is known as a safe and effective protein for
detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with …
detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with …
[HTML][HTML] Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1: cocaine hydrolysis pathway
Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose
Cocaine addiction is associated with compulsive drug seeking, and exposure to the drug or
to drug-associated cues leads to relapse, even after long periods of abstention. A variety of …
to drug-associated cues leads to relapse, even after long periods of abstention. A variety of …
[HTML][HTML] Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin
Heroin is a growing national crisis in America. There is an increasing frequency of heroin
overdoses. All of the currently used therapeutic approaches to treatment of heroin abuse …
overdoses. All of the currently used therapeutic approaches to treatment of heroin abuse …