Drug-induced gingival overgrowth (DIGO) is one of the side effects produced by therapeutic
agents, most commonly phenytoin, nifedipine and cyclosporin A. However, the precise …

Connective tissue growth factor (CTGF= CCN2), one of six members of cysteine‐rich,
secreted, heparin‐binding proteins with a modular structure, is recognized as an important …

Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect
approximately one million North Americans. Lesions occur principally as side-effects from …

The CCN (c yr61, c tgf, n ov) family of modular proteins regulate diverse biological affects
including cell adhesion, matrix production, tissue remodelling, proliferation and …

Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly
progressive, local or diffuse enlargements within marginal and attached gingiva or …

The development of fibrosis involves a multitude of events and molecules. Until now the
majority of these molecules were found to be proteins or peptides. But recent data show …

The complex mechanisms by which transforming growth factor β (TGFβ) regulate re-
epithelialisation following injury of stratified epithelia are not fully understood. TGFβ signals …

Unlike skin, oral gingival do not scar in response to tissue injury. Fibroblasts, the cell type
responsible for connective tissue repair and scarring, are exposed to mechanical tension …

Epithelial to mesenchymal transition (EMT) occurs normally in development. In pathology,
EMT drives cancer and fibrosis. Medication with phenytoin, nifedipine, and cyclosporine-A …

Variations in the balance between cell proliferation and apoptosis could contribute to the
etiology of gingival overgrowth. The aim of this study was to test the hypothesis that, in …