Personalized dynamic network models of the human brain as a future tool for planning and optimizing epilepsy therapy

I Dallmer‐Zerbe, P Jiruska, J Hlinka - Epilepsia, 2023 - Wiley Online Library
Epilepsy is a common neurological disorder, with one third of patients not responding to
currently available antiepileptic drugs. The proportion of pharmacoresistant epilepsies has …

Epilepsy as a dynamical disorder orchestrated by epileptogenic zone: a review

C Yang, Z Liu, Q Wang, Q Wang, Z Liu, G Luan - Nonlinear Dynamics, 2021 - Springer
Epilepsy is a group of chronic neurological disorders characterized with recurrent and
hypersynchronous discharge. In the epileptic brain, epileptogenic zone (EZ) with abnormal …

Computational modeling allows unsupervised classification of epileptic brain states across species

I Dallmer-Zerbe, N Jajcay, J Chvojka, R Janca… - Scientific Reports, 2023 - nature.com
Current advances in epilepsy treatment aim to personalize and responsively adjust
treatment parameters to overcome patient heterogeneity in treatment efficiency. For tailoring …

Network-motif delay differential analysis of brain activity during seizures

C Lainscsek, P Salami, VR Carvalho… - … Journal of Nonlinear …, 2023 - pubs.aip.org
Delay Differential Analysis (DDA) is a nonlinear method for analyzing time series based on
principles from nonlinear dynamical systems. DDA is extended here to incorporate network …

On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram

VR Cota, SAV Cançado, MFD Moraes - Frontiers in Neuroinformatics, 2023 - frontiersin.org
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

Unsupervised eeg preictal interval identification in patients with drug-resistant epilepsy

A Leal, J Curty, F Lopes, MF Pinto, A Oliveira… - Scientific Reports, 2023 - nature.com
Typical seizure prediction models aim at discriminating interictal brain activity from pre-
seizure electrographic patterns. Given the lack of a preictal clinical definition, a fixed interval …

Epilepsy surgery: Evaluating robustness using dynamic network models

L Junges, W Woldman, OJ Benjamin… - … Journal of Nonlinear …, 2020 - pubs.aip.org
Epilepsy is one of the most common neurological conditions affecting over 65 million people
worldwide. Over one third of people with epilepsy are considered refractory: they do not …

Heterogeneous correlate and potential diagnostic biomarker of tinnitus based on nonlinear dynamics of resting-state EEG recordings

Z Naghdabadi, M Jahed - Plos one, 2024 - journals.plos.org
Tinnitus is a heterogeneous condition of hearing a rattling sound when there is no auditory
stimulus. This rattling sound is associated with abnormal synchronous oscillations in …

Comparision of spontaneous brain activity between hippocampal sclerosis and MRI-negative temporal lobe epilepsy

C Song, X Zhang, Y Zhang, S Han, K Ma, X Mao… - Epilepsy & Behavior, 2024 - Elsevier
Background Hippocampal sclerosis (HS) is a prevalent cause of temporal lobe epilepsy
(TLE). However, up to 30% of individuals with TLE present negative magnetic resonance …

Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms

S Shariff, HA Nouh, S Inshutiyimana… - Health Science …, 2024 - Wiley Online Library
Introduction Epilepsy is characterized by having two or more unprovoked seizures.
Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular …