Regulation of immune responses by extracellular vesicles

PD Robbins, AE Morelli - Nature Reviews Immunology, 2014 - nature.com
Extracellular vesicles, including exosomes, are small membrane vesicles derived from
multivesicular bodies or from the plasma membrane. Most, if not all, cell types release …

Exosomes and their roles in immune regulation and cancer

DW Greening, SK Gopal, R Xu, RJ Simpson… - Seminars in cell & …, 2015 - Elsevier
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …

The biology and function of extracellular vesicles in immune response and immunity

R Kalluri - Immunity, 2024 - cell.com
Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins
and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Membrane vesicles as conveyors of immune responses

C Théry, M Ostrowski, E Segura - Nature reviews immunology, 2009 - nature.com
In multicellular organisms, communication between cells mainly involves the secretion of
proteins that then bind to receptors on neighbouring cells. But another mode of intercellular …

Biological roles and potential applications of immune cell-derived extracellular vesicles

C Wen, RC Seeger, M Fabbri, L Wang… - Journal of …, 2017 - Taylor & Francis
Extracellular vesicles (EVs) deliver bioactive macromolecules (ie proteins, lipids and nucleic
acids) for intercellular communication in multicellular organisms. EVs are secreted by all cell …

Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer

F Zeng, AE Morelli - Seminars in immunopathology, 2018 - Springer
Eukaryotic cells employ different types of extracellular vesicles (EVs) to exchange proteins,
mRNAs, non-coding regulatory RNAs, carbohydrates, and lipids. Cells of the immune …

Urinary exosomes: the potential for biomarker utility, intercellular signaling and therapeutics in urological malignancy

CA Franzen, RH Blackwell, KE Foreman… - The Journal of …, 2016 - auajournals.org
Purpose: Exosomes are small secreted vesicles that contain proteins, mRNA and miRNA
with the potential to alter signaling pathways in recipient cells. While exosome research has …

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes

U Gehrmann, S Hiltbrunner, AM Georgoudaki… - Cancer research, 2013 - AACR
Exosomes and the invariant NKT (iNKT) immune cell ligand α-galactosylceramide (αGC)
may offer novel tools for cancer immunotherapy. In this study, we investigated whether …

Harnessing the exosome-induced immune response for cancer immunotherapy

U Gehrmann, TI Näslund, S Hiltbrunner… - Seminars in Cancer …, 2014 - Elsevier
In recent years exosomes have emerged as potent stimulators of immune responses and as
agents for cancer therapy. Exosomes can carry a broad variety of immunostimulatory …