The use of the diffusion tensor imaging (DTI) is rapidly growing in the neuroimaging field.
Nevertheless, rigorously performed quantitative validation of DTI pathologic metrics remains …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Several MRI measures have been proposed as in vivo biomarkers of myelin, each with
applications ranging from plasticity to pathology. Despite the availability of these myelin …

Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

Abstract Introduction The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial
is an adaptive platform trial testing multiple drugs to slow or prevent the progression of …

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Quantitative diffusion imaging techniques enable the characterization of tissue
microstructural properties of the human brain “in vivo”, and are widely used in neuroscientific …

Myelin water imaging (MWI) is an MRI imaging biomarker for myelin. This method can
generate an in vivo whole‐brain myelin water fraction map in approximately 10 minutes. It …

Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple
sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of …