Diabetic retinopathy: vascular and inflammatory disease

F Semeraro, A Cancarini, R dell'Omo… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working‐age
population of the Western world. The pathogenesis of DR is complex and several vascular …

Endothelial dysfunction in diabetic retinopathy

F Gui, Z You, S Fu, H Wu, Y Zhang - Frontiers in Endocrinology, 2020 - frontiersin.org
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results
in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused …

Angiogenesis and inflammation crosstalk in diabetic retinopathy

M Capitão, R Soares - Journal of cellular biochemistry, 2016 - Wiley Online Library
Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of
diabetes and one of the most frequent causes of blindness in active age. Etiopathogenesis …

Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy

NPB Au, CHE Ma - Frontiers in Immunology, 2022 - frontiersin.org
Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or
indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit …

Inflammatory cytokines in diabetic nephropathy

J Donate-Correa, E Martín-Núñez… - Journal of diabetes …, 2015 - Wiley Online Library
Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy,
which is the largest single cause of end‐stage renal disease and a medical catastrophe of …

The role of inflammatory cytokines in diabetic nephropathy

JF Navarro-Gonzalez… - Journal of the American …, 2008 - journals.lww.com
Cytokines act as pleiotropic polypeptides regulating inflammatory and immune responses
through actions on cells. They provide important signals in the pathophysiology of a range of …

The innate immune system in diabetic retinopathy

WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

R Meshkani, S Vakili - Clinica chimica acta, 2016 - Elsevier
There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: A systematic review and meta-analysis

RH Mason, SA Minaker, G Lahaie Luna, P Bapat… - Eye, 2022 - nature.com
Background Diabetic retinopathy is a major complication of diabetes mellitus, where in its
most advanced form ischemic changes lead to the development of retinal …

Inflammation and diabetic retinal microvascular complications

W Zhang, H Liu, M Al-Shabrawey, RW Caldwell… - 2011 - Elsevier
Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a
leading cause of blindness in people of the working age in Western countries. A major …