[HTML][HTML] Pathogenic aspects and therapeutic avenues of autophagy in Parkinson's disease

R Kinet, B Dehay - Cells, 2023 - mdpi.com
The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …

X-linked dystonia parkinsonism: epidemiology, genetics, clinical features, diagnosis, and treatment

HL Chin, CY Lin, OHI Chou - Acta Neurologica Belgica, 2023 - Springer
X-linked dystonia parkinsonism (XDP) is a rare X-linked recessive degenerative movement
disorder that only affects Filipino descent, predominantly males. Its underlying cause is …

A network imaging biomarker of X‐linked dystonia‐parkinsonism

M Niethammer, CC Tang, RDG Jamora… - Annals of …, 2023 - Wiley Online Library
Objective The purpose of this study was to characterize a metabolic brain network
associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed …

[HTML][HTML] Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing

KT Tshilenge, J Bons, CG Aguirre… - Neurobiology of …, 2024 - Elsevier
X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the
Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type …

ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia–parkinsonism (XDP)

JL Rosenkrantz, JE Brandorff, S Raghib… - Proceedings of the …, 2024 - pnas.org
X-linked dystonia–parkinsonism (XDP) is a severe neurodegenerative disorder resulting
from an inherited intronic SINE-Alu-VNTR (SVA) retrotransposon in the TAF1 gene that …

Striatal cholinergic dysregulation after neonatal decrease in X‐linked dystonia parkinsonism‐related TAF1 isoforms

MD Cirnaru, J Creus‐Muncunill, S Nelson… - Movement …, 2021 - Wiley Online Library
Background X‐linked dystonia parkinsonism is a generalized, progressive dystonia followed
by parkinsonism with onset in adulthood and accompanied by striatal neurodegeneration …

G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism

G Nicoletto, M Terreri, I Maurizio… - Nucleic Acids …, 2024 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in
guanine (G)-rich genomic regions. X-linked dystonia parkinsonism (XDP) is an inherited …

Repeat‐Associated Non‐AUG Translation of AGAGGG Repeats that Cause X‐Linked Dystonia‐Parkinsonism

CJ Reyes, K Asano, PK Todd, C Klein… - Movement …, 2022 - Wiley Online Library
Background X‐linked dystonia‐parkinsonism (XDP) is a neurodegenerative disorder caused
by the intronic insertion of a SINE‐VNTR‐Alu (SVA) retrotransposon carrying an (AGAGGG) …

[HTML][HTML] Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat

LN Campion, A Mejia Maza, R Yadav… - Acta neuropathologica …, 2022 - Springer
X-linked dystonia-parkinsonism (XDP) is a progressive adult-onset neurodegenerative
disorder caused by insertion of a SINE-VNTR-Alu (SVA) retrotransposon in the TAF1 gene …

A scoping review on the diagnosis and treatment of X-linked dystonia-parkinsonism

AHD Alonto, RDG Jamora - Parkinsonism & Related Disorders, 2023 - Elsevier
Introduction X-linked dystonia-parkinsonism (XDP) is a progressive neurodegenerative
disorder that has been studied well in recent years. Objectives This scoping review aimed to …