Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly
distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are …

Genome-wide association studies of complex immune-mediated diseases have indicated
that many genetic factors, each with individual low risk, contribute to overall disease. It is …

The role of Hedgehog signaling in normal and malignant T-cell development is
controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but …

The thymus is a central hematopoietic organ which produces mature T lymphocytes with
diverse antigen specificity. During development, the thymus primordium is derived from the …

The hedgehog (HH) signaling pathway is a highly regulated signaling pathway that is
important not only for embryonic development, tissue patterning, and organogenesis but …