Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

Background: An increasing number of studies have shown that the brain–gut–microbiota
axis may significantly contribute to Alzheimer's disease (AD) pathogenesis. Moreover …

Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

Background Systemic bacterial infections often result in enduring cognitive impairment and
are a risk factor for dementia. There are currently no effective treatments for infection …

Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological
accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ …

Background The activation of nuclear factor‐kappa B (NF‐κB) and NLRP 3 inflammasome is
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …

Cannabinoids have been shown to exert neuroprotective effects in a plethora of
neurodegenerative conditions. Over the past decade, some studies demonstrate that …

Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …