Role of glutamate and NMDA receptors in Alzheimer's disease
Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …
The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …
implications. Clinical and experimental studies on aging have uncovered numerous …
Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine–searching for the connections
W Danysz, CG Parsons - British journal of pharmacology, 2012 - Wiley Online Library
β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …
d-glutamate and Gut Microbiota in Alzheimer's Disease
Background: An increasing number of studies have shown that the brain–gut–microbiota
axis may significantly contribute to Alzheimer's disease (AD) pathogenesis. Moreover …
axis may significantly contribute to Alzheimer's disease (AD) pathogenesis. Moreover …
Role of Aβ in Alzheimer's-related synaptic dysfunction
H Zhang, X Jiang, L Ma, W Wei, Z Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …
Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment
Background Systemic bacterial infections often result in enduring cognitive impairment and
are a risk factor for dementia. There are currently no effective treatments for infection …
are a risk factor for dementia. There are currently no effective treatments for infection …
Amyloid-β as a modulator of synaptic plasticity
MS Parihar, GJ Brewer - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological
accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ …
accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ …
Antimalarial drug Artemisinin extenuates amyloidogenesis and neuroinflammation in APP swe/PS 1dE9 Transgenic Mice via inhibition of nuclear factor‐κ B and NLRP …
JQ Shi, CC Zhang, XL Sun, XX Cheng… - CNS neuroscience & …, 2013 - Wiley Online Library
Background The activation of nuclear factor‐kappa B (NF‐κB) and NLRP 3 inflammasome is
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …
WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway
Cannabinoids have been shown to exert neuroprotective effects in a plethora of
neurodegenerative conditions. Over the past decade, some studies demonstrate that …
neurodegenerative conditions. Over the past decade, some studies demonstrate that …
Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets
SH Han, JC Park, I Mook-Jung - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …
modern society because of insurmountable difficulties in early diagnosis and lack of …