The diverse mechanisms and anticancer potential of naphthoquinones

CE Pereyra, RF Dantas, SB Ferreira, LP Gomes… - Cancer Cell …, 2019 - Springer
Cancer is one of the leading causes of death around the world and although the different
clinical approaches have helped to increase survival rates, incidence is still high and so its …

Understanding cancer and the anticancer activities of naphthoquinones–a review

KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

Electrochemical reduction of quinones in different media: a review

PS Guin, S Das, PC Mandal - International Journal of …, 2011 - Wiley Online Library
The electron transfer reactions involving quinones, hydroquinones, and catechols are very
important in many areas of chemistry, especially in biological systems. The therapeutic …

[HTML][HTML] Recent advances in 1, 4-benzoquinone chemistry

I Abraham, R Joshi, P Pardasani… - Journal of the Brazilian …, 2011 - SciELO Brasil
1, 4-Benzoquinones are ubiquitous in nature and can be synthesized by diverse strategies.
Recent developments on their synthetic methodologies, cycloaddition reactions …

Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

EA Hillard, FC de Abreu, DCM Ferreira… - Chemical …, 2008 - pubs.rsc.org
This review article summarizes recent applications of electrochemical techniques to redox-
active drug development and mechanistic studies. It includes a general introduction to the …

Morita–Baylis–Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs

CG Lima–Junior, MLAA Vasconcellos - Bioorganic & medicinal chemistry, 2012 - Elsevier
This review aims to present by the first time the Morita–Baylis–Hillman adducts (MBHA) as a
new class of bioactive compounds and highlight its potentialities to the discovery of new …

[HTML][HTML] Um panorama atual da química e da farmacologia de naftoquinonas, com ênfase na beta-lapachona e derivados

MN Silva, VF Ferreira, MCBV de Souza - Química Nova, 2003 - SciELO Brasil
Naphthoquinones have been extensively studied due to their activity as topoisomerase
inhibitors. These enzymes are critical to DNA replication in cells. In addition …

Syntheses of chromenes and chromanes via o‐quinone methide intermediates

SB Ferreira, FC da Silva, AC Pinto… - Journal of Heterocyclic …, 2009 - cir.nii.ac.jp
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[HTML][HTML] 1, 2, 3-Triazole-, arylamino-and thio-substituted 1, 4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C …

EHG da Cruz, CMB Hussene, GG Dias… - Bioorganic & Medicinal …, 2014 - Elsevier
Triazole-, arylamino-and thio-substituted naphthoquinones (24, 8, and 2 representatives,
respectively) were synthesized in moderate yields and evaluated against several human …

Biological activities of pyridoacridines

KM Marshall, LR Barrows - Natural product reports, 2004 - pubs.rsc.org
Covering: 1983–2003This review consolidates biological activity data reported for
pyridoacridine 1 molecules in the literature from 1983–2003 into several tables with brief …