Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health
expenditures worldwide. Obesity is a significant risk factor for CKD development, partially …

Background/objectives The weight loss following Semaglutide treatment, a GLP-1 receptor
agonist, might be responsible for some effects observed on the nonalcoholic fatty liver …

Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Despite their high degree of effectiveness in the management of psychiatric conditions,
exposure to antipsychotic drugs, including olanzapine and risperidone, is frequently …

Energy homeostasis is controlled by an intricate regulatory system centred in the brain. The
peripheral adiposity signals insulin and leptin play a crucial role in this system by informing …

BACKGROUND Obesity is a multifactorial disease with adverse health implications
including insulin resistance (IR). In patients with obesity, the presence of high circulating …

Partial leptin reduction can induce significant weight loss, while weight loss contributes to
partial leptin reduction. The cause-and-effect relationship between leptin reduction and …

Abstract Purpose of Review As obesity and chronic kidney disease (CKD) remain a public
health issue, we aim to elaborate on their complex relationship regarding pathogenetic …