Global HIV neurology: a comprehensive review

KT Thakur, A Boubour, D Saylor, M Das, DR Bearden… - Aids, 2019 - journals.lww.com
Neurological conditions associated with HIV remain major contributors to morbidity and
mortality and are increasingly recognized in the aging population on long-standing …

The CCL2/CCR2 axis in the pathogenesis of HIV-1 infection: a new cellular target for therapy?

D Angela Covino, M Sabbatucci… - Current drug targets, 2016 - ingentaconnect.com
The identification of chemokine receptors as necessary co-receptors for HIV entry into target
cells represented a breakthrough in the understanding of the pathogenesis of this viral …

Blood-brain barrier disruption is initiated during primary HIV infection and not rapidly altered by antiretroviral therapy

E Rahimy, FY Li, L Hagberg, D Fuchs… - The Journal of …, 2017 - academic.oup.com
Background. We explored the establishment of abnormal blood-brain barrier (BBB)
permeability and its relationship to neuropathogenesis during primary human …

Neurologic signs and symptoms frequently manifest in acute HIV infection

J Hellmuth, JLK Fletcher, V Valcour, E Kroon… - Neurology, 2016 - AAN Enterprises
Objective: To determine the incidence, timing, and severity of neurologic findings in acute
HIV infection (pre–antibody seroconversion), as well as persistence with combination …

Acute retroviral syndrome is associated with high viral burden, CD4 depletion, and immune activation in systemic and tissue compartments

TA Crowell, DJ Colby, S Pinyakorn… - Clinical Infectious …, 2018 - academic.oup.com
Background Many individuals with acute human immunodeficiency virus infection (AHI)
experience acute retroviral syndrome (ARS), which is associated with adverse long-term …

HIV neuropathy

M Kaku, DM Simpson - Current opinion in HIV and AIDS, 2014 - journals.lww.com
The prevalence of those affected by HIV-DSP will continue to grow with the aging population
of HIV-infected individuals. Compared to the diabetic neuropathy drug trials, trials in both …

[HTML][HTML] The role of T-lymphocytes in neuropathic pain initiation, development of chronicity and treatment

DA Galvin, C McCrory - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
Ongoing research has strongly suggested the role the immune system plays in the
pathogenesis of neuropathic pain. T cells appear to be one of the main regulators of the …

[HTML][HTML] Kynurenine, tetrahydrobiopterin, and cytokine inflammatory biomarkers in individuals affected by diabetic neuropathic pain

A Staats Pires, B Heng, VX Tan, A Latini… - Frontiers in …, 2020 - frontiersin.org
Neuropathic pain is a common complication of diabetes with high morbidity and poor
treatment outcomes. Accumulating evidence suggests the immune system is involved in the …

[HTML][HTML] Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early …

R Wodarski, D Bagdas, JJ Paris, T Pheby, W Toma… - Pain …, 2018 - journals.lww.com
Results: Intraepidermal nerve fibre density was significantly reduced after 6 weeks of Tat
induction, similar to sensory neuropathy seen in clinical HIV infection. Tat induction through …

Neurologic sequelae of primary HIV infection

BJ Brew, JY Garber - Handbook of Clinical Neurology, 2018 - Elsevier
Primary human immunodeficiency virus type 1 (HIV-1) infection is defined as the period from
initial infection with HIV to complete seroconversion. Neurologic sequelae of primary HIV-1 …