Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …

Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …

The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP
synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has …

Microbial stimuli such as lipopolysaccharide (LPS) induce robust metabolic rewiring in
immune cells known as the Warburg effect. It is unknown whether this increase in glycolysis …

Retinal ganglion cells (RGC s) are the sole projecting neurons of the retina and their axons
form the optic nerve. Here, we show that embryogenesis‐associated mouse RGC …