Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …
considered only as pathological aggregates implicated in human neurodegenerative …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Fundamentals of cross-seeding of amyloid proteins: an introduction
Misfolded protein aggregates formed by the same (homologous) or different
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease
I Horvath, P Wittung-Stafshede - Proceedings of the …, 2016 - National Acad Sciences
In type-2 diabetes (T2D) and Parkinson's disease (PD), polypeptide assembly into amyloid
fibers plays central roles: in PD, α-synuclein (aS) forms amyloids and in T2D, amylin [islet …
fibers plays central roles: in PD, α-synuclein (aS) forms amyloids and in T2D, amylin [islet …
The early events that initiate β-amyloid aggregation in Alzheimer's disease
X Zhang, Z Fu, L Meng, M He, Z Zhang - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is characterized by the development of amyloid plaques and
neurofibrillary tangles (NFTs) consisting of aggregated β-amyloid (Aβ) and tau, respectively …
neurofibrillary tangles (NFTs) consisting of aggregated β-amyloid (Aβ) and tau, respectively …
Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells
P Bharadwaj, T Solomon, BR Sahoo, K Ignasiak… - Scientific Reports, 2020 - nature.com
Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate
in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that …
in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that …
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's
and type II diabetes (among many others) features a bewildering variety of β-sheet-rich …
and type II diabetes (among many others) features a bewildering variety of β-sheet-rich …
[HTML][HTML] IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies
Islet amyloid polypeptide (aka IAPP, amylin) is a 37 amino acid hormone that has long been
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …
In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture
M Richman, S Wilk, M Chemerovski… - Journal of the …, 2013 - ACS Publications
Misfolding of the Aβ protein and its subsequent aggregation into toxic oligomers are related
to Alzheimer's disease. Although peptides of various sequences can self-assemble into …
to Alzheimer's disease. Although peptides of various sequences can self-assemble into …