Artificial intelligence and pathomics: prostate cancer

PA Moghadam, A Bashashati… - Urologic …, 2024 - urologic.theclinics.com
Since the introduction of the hematoxylin and eosin (H&E)-stained slide in 1876 as the
primary tool in the pathologist's toolbox up until the last decade, few tools, other than the …

PSA velocity and doubling time in diagnosis and prognosis of prostate cancer

AJ Vickers, SF Brewster - British Journal of Medical and …, 2012 - journals.sagepub.com
Cancer is a growth process and it is natural that we should be concerned with how the
routinely used marker of prostate cancer tumour burden–PSA–changes over time. Such …

Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study

J Cuzick, GP Swanson, G Fisher, AR Brothman… - The lancet …, 2011 - thelancet.com
Background Optimum management of clinically localised prostate cancer presents unique
challenges because of the highly variable and often indolent natural history of the disease …

Outcomes of localized prostate cancer following conservative management

GL Lu-Yao, PC Albertsen, DF Moore, W Shih, Y Lin… - Jama, 2009 - jamanetwork.com
Context Most newly diagnosed prostate cancers are clinically localized, and major treatment
options include surgery, radiation, or conservative management. Although conservative …

Validation of an RNA cell cycle progression score for predicting death from prostate cancer in a conservatively managed needle biopsy cohort

J Cuzick, S Stone, G Fisher, ZH Yang, BV North… - British journal of …, 2015 - nature.com
Background: The natural history of prostate cancer is highly variable and difficult to predict
accurately. Better markers are needed to guide management and avoid unnecessary …

Molecular sampling of prostate cancer: a dilemma for predicting disease progression

A Sboner, F Demichelis, S Calza, Y Pawitan… - BMC medical …, 2010 - Springer
Background Current prostate cancer prognostic models are based on pre-treatment prostate
specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are …

PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volume

EJ Whitman, J Groskopf, A Ali, Y Chen… - The Journal of …, 2008 - auajournals.org
Purpose: PCA3 is a prostate specific, nonprotein coding RNA that is over expressed in
prostate cancer. Recent studies showed the diagnostic potential of a urine based PCA3 for …

Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study

DM Berney, A Gopalan, S Kudahetti, G Fisher… - British journal of …, 2009 - nature.com
Abstract Treatment decisions after diagnosis of clinically localised prostate cancer are
difficult due to variability in tumour behaviour. We therefore examined one of the most …

Prognostic role of neutrophil-to-lymphocyte ratio in prostate cancer: a systematic review and meta-analysis

X Yin, Y Xiao, F Li, S Qi, Z Yin, J Gao - Medicine, 2016 - journals.lww.com
Inflammation is increasingly reported to be associated with the prognosis of patients with
cancers. And the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with …

Evaluating localized prostate cancer and identifying candidates for focal therapy

AO Sartor, H Hricak, TM Wheeler, J Coleman… - Urology, 2008 - Elsevier
Can focal therapy successfully control prostate cancer? Also, if so, which patients should be
considered eligible? With limited data available from relatively few patients, these questions …