[HTML][HTML] Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

S Halldorsson, E Lucumi, R Gómez-Sjöberg… - Biosensors and …, 2015 - Elsevier
Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell …

[PDF][PDF] Stem cell models of human brain development

I Kelava, MA Lancaster - Cell stem cell, 2016 - cell.com
Recent breakthroughs in pluripotent stem cell technologies have enabled a new class of in
vitro systems for functional modeling of human brain development. These advances, in …

[HTML][HTML] Recent advances in microfluidic technologies for cell-to-cell interaction studies

M Rothbauer, H Zirath, P Ertl - Lab on a Chip, 2018 - pubs.rsc.org
Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …

An atlas of nano-enabled neural interfaces

H Acarón Ledesma, X Li, JL Carvalho-de-Souza… - Nature …, 2019 - nature.com
Advances in microscopy and molecular strategies have allowed researchers to gain insight
into the intricate organization of the mammalian brain and the roles that neurons play in …

Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues

YM Efremov, IM Zurina, VS Presniakova… - Biophysical …, 2021 - Springer
Cell aggregates, including sheets and spheroids, represent a simple yet powerful model
system to study both biochemical and biophysical intercellular interactions. However, it is …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

[HTML][HTML] Functional characterization of human pluripotent stem cell-derived models of the brain with microelectrode arrays

A Pelkonen, C Pistono, P Klecki, M Gómez-Budia… - Cells, 2021 - mdpi.com
Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

Compartmentalized microfluidic platforms: the unrivaled breakthrough of in vitro tools for neurobiological research

E Neto, L Leitão, DM Sousa, CJ Alves… - Journal of …, 2016 - Soc Neuroscience
Microfluidic technology has become a valuable tool to the scientific community, allowing
researchers to study fine cellular mechanisms with higher variable control compared with …

Integration of reconfigurable microchannels into aligned three-dimensional neural networks for spatially controllable neuromodulation

S Jeong, HW Kang, SH Kim, GS Hong, MH Nam… - Science …, 2023 - science.org
Anisotropically organized neural networks are indispensable routes for functional
connectivity in the brain, which remains largely unknown. While prevailing animal models …

[HTML][HTML] Functional bioengineered models of the central nervous system

N Rouleau, NJ Murugan, DL Kaplan - Nature Reviews Bioengineering, 2023 - nature.com
The functional complexity of the central nervous system (CNS) is unparalleled in living
organisms. Its nested cells, circuits and networks encode memories, move bodies and …