Determining whether and how a gene is transcribed are two of the central processes of life.
The conceptual basis for understanding such gene regulation arose from pioneering …

The linear framework uses finite, directed graphs with labelled edges to model biomolecular
systems. Graph vertices represent biochemical species or molecular states, edges represent …

Predicting how interactions between transcription factors and regulatory DNA sequence
dictate rates of transcription and, ultimately, drive developmental outcomes remains an open …

Connecting the developmental patterning of tissues to the mechanistic control of RNA
polymerase II remains a long-term goal of developmental biology. Many key elements have …

The eukaryotic transcription cycle consists of three main steps: initiation, elongation, and
cleavage of the nascent RNA transcript. Although each of these steps can be regulated as …

During development, gene regulatory networks allocate cell fates by partitioning tissues into
spatially organised domains of gene expression. How the sharp boundaries that delineate …

Cell states result from the ordered activation of gene expression by transcription factors.
Transcription factors face opposing design constraints: they need to be dynamic to trigger …

Cells adapt to changing environments by sensing ligand concentrations using specific
receptors. The accuracy of sensing is ultimately limited by the finite number of ligand …

Cell division events require regulatory systems to ensure that events happen in a distinct
order. The classic view of temporal control of the cell cycle posits that cells order events by …

In developing embryos, cells acquire distinct identities depending on their position in a
tissue. Secreted signalling molecules, known as morphogens, act as long-range cues to …