Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers
that enable safe and efficient intracellular delivery. Before the desired site of action is …

Chitosan is increasingly used for safe nucleic acid delivery in gene therapy studies, due to
well-known properties such as bioadhesion, low toxicity, biodegradability and …

Bioreducible polymers have appeared as ideal gene delivery vectors due to the high
stability in extracellular fluids and rapid DNA unpacking in an intracellular reducing …

To improve transfection efficiency of nonviral vectors, biotinylated chitosan was applied to
complex with DNA in different N/P ratios. The morphologies and the sizes of formed …

Objectives Previously, we reported the improved transfection efficiency of a plasmid DNA-
chitosan (pDNA-CS) complex using a phosphorylatable nuclear localization signal-linked …

Purpose Mechanism study of why astrocytes isolated from experimental autoimmune
encephalomyelitis (EAE)-induced B6 mice or after being exposed to inflammatory factors …

The aim of the present study was to investigate the effects of phosphorylatable nucleus
localization signal linked nucleic kinase substrate short peptide (pNNS)‐conjugated …

Previously, we reported an improvement in the transfection efficiency of the plasmid DNA-
chitosan (pDNA/CS) complex by the utilization of phosphorylatable short peptide-conjugated …

A spatial effect of targeted signal distribution is found in catiomer–gene polyplexes which
strongly influences the gene transfection profiles. The nuclear localization sequence …

A number of studies have indicated that thyroid hormone receptor β1 (TRβ1) functions as a
tumor suppressor. TRs mediate transcriptional responses through a highly conserved DNA …