The mRNA coding sequence defines not only the amino acid sequence of the protein, but
also the speed at which the ribosomes move along the mRNA while making the protein. The …

Metabolism and mRNA translation represent critical steps involved in modulating gene
expression and cellular physiology. Being the most energy-consuming process in the cell …

The most abundant N 6-methyladenosine (m 6 A) modification on mRNAs is installed non-
stoichiometrically across transcripts, with 5′ untranslated regions (5′ UTRs) being the …

Protein and vaccine therapies based on mRNA would benefit from an increase in translation
capacity. Here, we report a method to augment translation named ligation-enabled mRNA …

Protein–RNA complexes exist in many forms within the cell, from stable machines such as
the ribosome to transient assemblies like the spliceosome. All protein–RNA assemblies rely …

N 6-methyladenosine (m6A) is an important modified nucleoside in cellular RNA associated
with multiple cellular processes and is implicated in diseases. The enzymes associated with …

Long-read sequencing technology enables highly accurate detection of allele-specific RNA
expression, providing insights into the effects of genetic variation on splicing and RNA …

The resistance of cancer cells to treatment significantly impedes the success of therapy,
leading to the recurrence of various types of cancers. Understanding the specific …

Diabetic nephropathy (DN) is one of the most common microvascular complications of
diabetes mellitus, characterized by progressive deterioration of renal structure and function …

Abstract tRNAs are essential molecules in protein synthesis, responsible for translating the
four-nucleotide genetic code into the corresponding amino acid sequence. RNA …