Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer
JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …
hyperinsulinemia. However, recent data suggest a reverse order and place …
The relationship between diabetes mellitus and cancers and its underlying mechanisms
B Zhu, S Qu - Frontiers in Endocrinology, 2022 - frontiersin.org
Epidemiological studies suggest associations between diabetes mellitus and some cancers.
The risk of a number of cancers appears to be increased in diabetes mellitus. On the other …
The risk of a number of cancers appears to be increased in diabetes mellitus. On the other …
Metformin in cancer
R Mallik, TA Chowdhury - Diabetes research and clinical practice, 2018 - Elsevier
Metformin is a lipophilic biguanide which inhibits hepatic gluconeogenesis and improves
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …
Role of epicardial adipose tissue in cardiovascular diseases: a review
M Konwerski, A Gąsecka, G Opolski, M Grabowski… - Biology, 2022 - mdpi.com
Simple Summary Cardiovascular diseases (CVDs) are the leading causes of death
worldwide. Epicardial adipose tissue (EAT) is one of the most important risk factors for …
worldwide. Epicardial adipose tissue (EAT) is one of the most important risk factors for …
The diabetic cardiomyopathy: the contributing pathophysiological mechanisms
T Salvatore, PC Pafundi, R Galiero, G Albanese… - Frontiers in …, 2021 - frontiersin.org
Individuals with diabetes mellitus (DM) disclose a higher incidence and a poorer prognosis
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …
Effects of metformin in heart failure: From pathophysiological rationale to clinical evidence
T Salvatore, R Galiero, A Caturano, E Vetrano… - Biomolecules, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a worldwide major health burden and heart failure (HF)
is the most common cardiovascular (CV) complication in affected patients. Therefore …
is the most common cardiovascular (CV) complication in affected patients. Therefore …
Cardiovascular benefits from gliflozins: effects on endothelial function
T Salvatore, A Caturano, R Galiero, A Di Martino… - Biomedicines, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a known independent risk factor for atherosclerotic
cardiovascular disease (CVD) and solid epidemiological evidence points to heart failure …
cardiovascular disease (CVD) and solid epidemiological evidence points to heart failure …
[HTML][HTML] Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease
R Galiero, A Caturano, E Vetrano, A Cesaro… - Reviews in …, 2021 - imrpress.com
Evidence suggests a close connection between Nonalcoholic Fatty Liver Disease (NAFLD)
and increased cardiovascular (CV) risk. Several cross-sectional studies report that NAFLD is …
and increased cardiovascular (CV) risk. Several cross-sectional studies report that NAFLD is …
Targeting of the tumor immune microenvironment by metformin
Z Wu, C Zhang, M Najafi - Journal of cell communication and signaling, 2022 - Springer
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence
A hyperglycemic state, also in non-diabetic subjects, may be associated with acute coronary
syndrome (ACS). Aim of this review is to describe the pathophysiologic association between …
syndrome (ACS). Aim of this review is to describe the pathophysiologic association between …