The human gamma herpesviruses, Kaposi sarcoma-associated virus (KSHV) and EBV, are
associated with multiple cancers. Recent evidence suggests that EBV and possibly other …

The ubiquitous Epstein Barr virus (EBV) exploits human B‐cell development to establish a
persistent infection in∼ 90% of the world population. Constitutive activation of NF‐κB by the …

CD40 has major roles in B cell development, activation, and germinal center responses.
CD40 hypoactivity causes immunodeficiency whereas its overexpression causes …

Epstein–Barr virus (EBV) persists for the life of the host by accessing the long-lived memory
B cell pool. It has been proposed that EBV uses different combinations of viral proteins …

ABSTRACT The Epstein-Barr virus protein latent membrane protein 1 (LMP1) has two NF-κB
activating domains within its intracellular carboxy terminus (carboxy-terminal activating …

Abstract Background Members of Tumor Necrosis Factor (TNF) Receptor-Associated Factors
(TRAFs) family interact with the cytoplasmic tails of TNF receptor family members to mediate …

Epstein Barr virus latent membrane protein 1 (LMP1) induces NF-κB activation through
transformation effector sites (TES) 1 and 2, both of which are critical for B-lymphocyte …

Résumé Le virus Epstein-Barr (EBV) est un gamma herpèsvirus humain infectant plus de
95% de la population mondiale. Lorsque la primo-infection a lieu pendant l'adolescence ou …

3.3. 1 EREB2-5 cells gain a memory B cell phenotype upon EBNA2 inactivation.............. 44
3.3. 2 Generation of the expression vectors coding for LMP1, LMP2A and EBNA1........... 45 …

Les proprotéines convertases (PCs) sont des enzymes impliquées de nombreux processus
pathologiques. Nous avons étudié deux substrats des PCs: l'apeline et la glycoprotéine B …