Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life
How, when, and why organisms age are fascinating issues that can only be fully addressed
by adopting an evolutionary perspective. Consistently, the main evolutionary theories of …
by adopting an evolutionary perspective. Consistently, the main evolutionary theories of …
Human cerebral organoid implantation alleviated the neurological deficits of traumatic brain injury in mice
Z Bao, K Fang, Z Miao, C Li, C Yang… - Oxidative medicine …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) causes a high rate of mortality and disability, and its treatment is
still limited. Loss of neurons in damaged area is hardly rescued by relative molecular …
still limited. Loss of neurons in damaged area is hardly rescued by relative molecular …
DLX genes and proteins in mammalian forebrain development
JL Rubenstein, AS Nord, M Ekker - Development, 2024 - journals.biologists.com
The vertebrate Dlx gene family encode homeobox transcription factors that are related to the
Drosophila Distal-less (Dll) gene and are crucial for development. Over the last∼ 35 years …
Drosophila Distal-less (Dll) gene and are crucial for development. Over the last∼ 35 years …
Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment
JW Adams, A Vinokur, JS de Souza, C Austria… - Cell reports, 2024 - cell.com
Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by
hemizygous loss of 26–28 genes at 7q11. 23, characteristically portray a hypersocial …
hemizygous loss of 26–28 genes at 7q11. 23, characteristically portray a hypersocial …
Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7
P Chen, J Long, T Hua, Z Zheng, Y Xiao… - Journal of Translational …, 2024 - Springer
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …
Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region
S Campeau, C McNulty, JT Stanley… - Frontiers in …, 2023 - frontiersin.org
Chronic stress is epidemiologically correlated with physical and psychiatric disorders.
Whereas many animal models of chronic stress induce symptoms of psychopathology …
Whereas many animal models of chronic stress induce symptoms of psychopathology …
Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours
R Aouci, M El Soudany, Z Maakoul, A Fontaine… - Cells, 2022 - mdpi.com
Neuronal circuits integrating Parvalbumin-positive GABAergic inhibitory interneurons (PV)
are essential for normal brain function and are often altered in psychiatric conditions. During …
are essential for normal brain function and are often altered in psychiatric conditions. During …
Neanderthal, Sapiens, and chimpanzee mandibles: A comparative study in relation to articulated speech
A Bermejo-Fenoll, A Panchón-Ruíz… - Archaeological and …, 2022 - Springer
Various studies have related morphology to bipedalism, type of diet, or chewing. However,
the studies so far that relate morphology to language are quite vague or incomplete. The aim …
the studies so far that relate morphology to language are quite vague or incomplete. The aim …
Self-domestication: from analogy to homology via genomics
C Boeckx, A Vitriolo, G Testa - 2022 - osf.io
This paper seeks to clarify central aspects of the “self-domestication” hypothesis and its
implications for the evolution of our species. It does so by reconstructing the evolutionary …
implications for the evolution of our species. It does so by reconstructing the evolutionary …
TrkB-dependent antidepressants action involves Dlx5/6 inhibition in cortical GABAergic neurons.
N Narboux-Nême, R Aouci, A Fontaine, A Vion, G Levi… - 2024 - researchsquare.com
Major depressive disorder (MDD) is a complex and devastating illness that affects people of
all ages. However, both the aetiology of MDD and the mechanisms of action of …
all ages. However, both the aetiology of MDD and the mechanisms of action of …