Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life

E Bapteste, P Huneman, L Keller, J Teulière… - Ageing Research …, 2023 - Elsevier
How, when, and why organisms age are fascinating issues that can only be fully addressed
by adopting an evolutionary perspective. Consistently, the main evolutionary theories of …

Human cerebral organoid implantation alleviated the neurological deficits of traumatic brain injury in mice

Z Bao, K Fang, Z Miao, C Li, C Yang… - Oxidative medicine …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) causes a high rate of mortality and disability, and its treatment is
still limited. Loss of neurons in damaged area is hardly rescued by relative molecular …

DLX genes and proteins in mammalian forebrain development

JL Rubenstein, AS Nord, M Ekker - Development, 2024 - journals.biologists.com
The vertebrate Dlx gene family encode homeobox transcription factors that are related to the
Drosophila Distal-less (Dll) gene and are crucial for development. Over the last∼ 35 years …

Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment

JW Adams, A Vinokur, JS de Souza, C Austria… - Cell reports, 2024 - cell.com
Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by
hemizygous loss of 26–28 genes at 7q11. 23, characteristically portray a hypersocial …

Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7

P Chen, J Long, T Hua, Z Zheng, Y Xiao… - Journal of Translational …, 2024 - Springer
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by
KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal …

Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region

S Campeau, C McNulty, JT Stanley… - Frontiers in …, 2023 - frontiersin.org
Chronic stress is epidemiologically correlated with physical and psychiatric disorders.
Whereas many animal models of chronic stress induce symptoms of psychopathology …

Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours

R Aouci, M El Soudany, Z Maakoul, A Fontaine… - Cells, 2022 - mdpi.com
Neuronal circuits integrating Parvalbumin-positive GABAergic inhibitory interneurons (PV)
are essential for normal brain function and are often altered in psychiatric conditions. During …

Neanderthal, Sapiens, and chimpanzee mandibles: A comparative study in relation to articulated speech

A Bermejo-Fenoll, A Panchón-Ruíz… - Archaeological and …, 2022 - Springer
Various studies have related morphology to bipedalism, type of diet, or chewing. However,
the studies so far that relate morphology to language are quite vague or incomplete. The aim …

Self-domestication: from analogy to homology via genomics

C Boeckx, A Vitriolo, G Testa - 2022 - osf.io
This paper seeks to clarify central aspects of the “self-domestication” hypothesis and its
implications for the evolution of our species. It does so by reconstructing the evolutionary …

TrkB-dependent antidepressants action involves Dlx5/6 inhibition in cortical GABAergic neurons.

N Narboux-Nême, R Aouci, A Fontaine, A Vion, G Levi… - 2024 - researchsquare.com
Major depressive disorder (MDD) is a complex and devastating illness that affects people of
all ages. However, both the aetiology of MDD and the mechanisms of action of …