The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

JK Gjerstad, SL Lightman, F Spiga - Stress, 2018 - Taylor & Francis
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex

BS McEwen, C Nasca, JD Gray - Neuropsychopharmacology, 2016 - nature.com
The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

YQ Ping, C Mao, P Xiao, RJ Zhao, Y Jiang, Z Yang… - Nature, 2021 - nature.com
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited
knowledge of their ligand regulation or structure is available,–. Here we report that …

Dynamic adaptation of large-scale brain networks in response to acute stressors

EJ Hermans, MJAG Henckens, M Joëls… - Trends in …, 2014 - cell.com
Stress initiates an intricate response that affects diverse cognitive and affective domains,
with the goal of improving survival chances in the light of changing environmental …

Stress, the stress system and the role of glucocorticoids

NC Nicolaides, E Kyratzi… - …, 2014 - karger.com
All living organisms have developed a highly conserved and regulatory system, the stress
system, to cope with a broad spectrum of stressful stimuli that threaten, or are perceived as …

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

M Popoli, Z Yan, BS McEwen… - Nature Reviews …, 2012 - nature.com
Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

Estrogen effects on cognitive and synaptic health over the lifecourse

Y Hara, EM Waters, BS McEwen… - Physiological …, 2015 - journals.physiology.org
Estrogen facilitates higher cognitive functions by exerting effects on brain regions such as
the prefrontal cortex and hippocampus. Estrogen induces spinogenesis and synaptogenesis …

The neuro-symphony of stress

M Joëls, TZ Baram - Nature reviews neuroscience, 2009 - nature.com
The impact of stress on brain function is increasingly recognized. Various substances are
released in response to stress and can influence distinct neuronal circuits, but the functional …

Genomic and epigenomic mechanisms of glucocorticoids in the brain

JD Gray, JF Kogan, J Marrocco… - Nature Reviews …, 2017 - nature.com
Following the discovery of glucocorticoid receptors in the hippocampus and other brain
regions, research has focused on understanding the effects of glucocorticoids in the brain …