Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …

In specialized secretory cells that produce and release biologically active substances in a
regulated fashion, tight control of both the quantity and quality of secretory material is of …

Mitochondria play a pivotal role in the generation of signals coupling metabolism with
neurotransmitter release, but a role for mitochondrial-produced ROS in regulating …

Abstract Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein
Sorting (HOPS) complex required for lysosomal fusion events and, independent of HOPS …

Abstract The SNAREs Vti1a/1b are implicated in regulated secretion, but their role relative to
canonical exocytic SNAREs remains elusive. Here, we show that synaptic vesicle and dense …

Dense core vesicles (DCVs) and synaptic vesicles are specialised secretory vesicles in
neurons and neuroendocrine cells, and abnormal release of their cargo is associated with …

It is today widely accepted that several types of high molecular weight (MW)
neurotransmitters produced by neurons are synthesized at the cell body, selectively stored …

Epithelial cell physiology critically depends on the asymmetric distribution of channels and
transporters. However, the mechanisms targeting membrane proteins to the apical surface …

It is well known that peptide hormones and neurotrophic factors are intercellular messengers
that are packaged into secretory vesicles in endocrine cells and neurons and released by …

In pancreatic β-cells, insulin granule membranes are enriched in cholesterol and are both
recycled and newly generated. Cholesterol's role in supporting granule membrane formation …