From nature to industry: Harnessing enzymes for biocatalysis
Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …
in countless applications from bench scale to industrial production and allows practitioners …
Engineering new catalytic activities in enzymes
The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …
chemists to consider biocatalytic transformations to complement or even supplant more …
Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning
While AlphaFold2 can predict accurate protein structures from the primary sequence,
challenges remain for proteins that undergo conformational changes or for which few …
challenges remain for proteins that undergo conformational changes or for which few …
Evolution of pyrrolysyl-tRNA synthetase: From methanogenesis to genetic code expansion
Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …
This perspective is primarily aimed at synthetic organic chemists with limited experience …
Broadening the scope of biocatalysis in sustainable organic synthesis
RA Sheldon, D Brady - ChemSusChem, 2019 - Wiley Online Library
This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …
De novo metalloprotein design
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …
and catalysis—in which the position and property of each ligand and metal are dictated by …
Stereocontrolled 1, 3-nitrogen migration to access chiral α-amino acids
Abstract α-Amino acids are essential for life as building blocks of proteins and components
of diverse natural molecules. In both industry and academia, the incorporation of unnatural …
of diverse natural molecules. In both industry and academia, the incorporation of unnatural …
Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids
The conversion of C‒H bonds to C‒N bonds offers a sustainable and economical strategy
for the synthesis of nitrogen-containing compounds. However, challenges regarding the …
for the synthesis of nitrogen-containing compounds. However, challenges regarding the …
The limits to biocatalysis: pushing the envelope
RA Sheldon, D Brady - Chemical communications, 2018 - pubs.rsc.org
In the period 1985 to 1995 applications of biocatalysis, driven by the need for more
sustainable manufacture of chemicals and catalytic,(enantio) selective methods for the …
sustainable manufacture of chemicals and catalytic,(enantio) selective methods for the …