Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …

Neurons transmit and receive information at specialized junctions called synapses.
Excitatory synapses form at the junction between a presynaptic axon terminal and a …

Neurotransmission in complex animals depends on a choir of functionally distinct synapses
releasing neurotransmitters in a highly coordinated manner. During synaptic signaling …

The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …

The exocytosis of synaptic vesicles (SVs) elicited by potent stimulation is rapidly
compensated by bulk endocytosis of SV membranes leading to large endocytic vacuoles …

Immune therapeutics holds great promise in the treatment of type 1 diabetes (T1D).
Nonetheless, their progress is hampered by limited efficacy, equipoise, or issues of safety …

Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells.
Dynamin controls various steps of the intoxication process used by numerous pathogenic …

The cortical actin network is a tight array of filaments located beneath the plasma
membrane. In neurosecretory cells, secretory vesicles are recruited on this network via a …

Over the past years, dynamin has been implicated in tuning the amount and nature of
transmitter released during exocytosis. However, the mechanism involved remains poorly …

Summary Clathrin/AP1-and clathrin/AP3-coated vesicular carriers originate from endosomes
and the trans-Golgi network. Here, we report the real-time visualization of these structures in …