The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …

Significant advances have taken place in our knowledge of the enzymes involved in steroid
hormone biosynthesis since the last comprehensive review in 1988. Major developments …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

▪ Abstract Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones
and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

The endoplasmic reticulum (ER) in animal cells is an extensive, morphologically continuous
network of membrane tubules and flattened cisternae. The ER is a multifunctional organelle; …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

Cholesterol is a vital component of cellular membranes, and is the substrate for biosynthesis
of steroids, oxysterols and bile acids. The mechanisms directing the intracellular trafficking of …