Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …

Interleukin-6 is a pleiotropic cytokine which plays a crucial role in immune physiology and is
tightly controlled by hormonal feedback mechanisms. After menopause or andropause, loss …

The role of two adipocytokines, adiponectin and leptin, in Taiwanese breast cancer patients
remains to be determined. In this study, we analyzed the correlations between the serum …

BACKGROUND: Reactive oxygen species (ROS), including superoxide anion radical (O2−),
plays an important role in carcinogenesis. The human body has developed different …

Immune therapies targeting the PD-1/PD-L1 pathway have been employed in the treatment
of breast cancer, which requires aerobic glycolysis to sustain breast cancer cells growth …

Cancer is the disease with highest public health impact in developed countries. Particularly,
breast cancer has the highest incidence in women worldwide and the fifth highest mortality …

Background: Breast cancer is caused by breast tissue malignant cells and it has become
one of the main medical concerns with a socio-economic significance especially for women …

Constitutive activation of Akt or nuclear factor-κB (NF-κB) has been reported to play a role in
de novo resistance of cancer cells to chemotherapeutic agents, which is a major cause of …

OBJECTIVES.: Features of deregulated Notch1 signaling and NF-κB activation have
independently been reported in cervical cancers. Here, we have extended these …

Resveratrol is an active polyphenol found in red wine that has anti-cancer effects, but the
molecular mechanisms of resveratrol on tumor invasion inhibition have not been well …