“Footprinting” refers to assays that examine ligand binding and conformational changes by
determining the solvent accessibility of the backbone, bases, or side chain structures of …

Gelsolin superfamily members are Ca2+‐dependent, multidomain regulators of the actin
cytoskeleton. Calcium binding activates gelsolin by inducing molecular gymnastics (large …

Cytoskeletal rearrangement occurs in a variety of cellular processes and involves a wide
spectrum of proteins. Among these, the gelsolin superfamily proteins control actin …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Abstract Gelsolin, a Ca2+‐regulated actin filament severing, capping, and nucleating
protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …

Structural proteomics approaches using mass spectrometry are increasingly used in biology
to examine the composition and structure of macromolecules. Hydroxyl radical–mediated …

Using mass spectrometry (MS) to obtain information about a higher order structure of protein
requires that a protein's structural properties are encoded into the mass of that protein …

Hydroxyl radical-mediated protein footprinting is a convenient and sensitive technique for
mapping solvent-accessible surfaces of proteins and examining the structure and dynamics …

Covalent labeling of proteins in combination with mass spectrometry has been established
as a complementary technique to classical structural methods, such as X-ray, NMR, or …