[HTML][HTML] Serotonergic Psychedelics–a Comparative review Comparing the Efficacy, Safety, Pharmacokinetics and Binding Profile of Serotonergic Psychedelics

F Holze, N Singh, ME Liechti, DC D'Souza - … : Cognitive Neuroscience and …, 2024 - Elsevier
Psychedelic compounds, including psilocybin, LSD, DMT, and 5-MeO-DMT all of which are
serotonin (5-HT) 2A receptor agonists are being investigated as potential treatments. This …

The risk of chronic psychedelic and MDMA microdosing for valvular heart disease

M Tagen, D Mantuani, L van Heerden… - Journal of …, 2023 - journals.sagepub.com
Psychedelic microdosing is the practice of taking very low doses of psychedelic substances,
typically over a longer period of time. The long-term safety of chronic microdosing is …

A brief historical overview of psychedelic research

MA Geyer - Biological Psychiatry: Cognitive Neuroscience and …, 2023 - Elsevier
Classical serotonergic psychedelics such as lysergic acid diethylamide (LSD) or the
naturally occurring compounds psilocybin and mescaline produce profound changes in …

Safety and risk assessment of psychedelic psychotherapy: a meta-analysis and systematic review

B Romeo, E Kervadec, B Fauvel, L Strika-Bruneau… - Psychiatry …, 2024 - Elsevier
Psychotherapies assisted by psychedelic substances have shown promising results in the
treatment of psychiatric disorders. The aim of this systematic review and meta-analysis was …

A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets

J Biosca-Brull, G Ona, L Alarcón-Franco… - Translational …, 2024 - nature.com
Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the
mechanisms that may underlie its anti-addictive effects are still not defined. This study aims …

Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response

AE Calder, B Rausch, ME Liechti… - Journal of …, 2024 - journals.sagepub.com
Background: Psychedelic-assisted therapy (PAT) is permitted in Switzerland under its limited
medical use program. Data from patients in this program represent a unique opportunity to …

The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies

K Stocker, M Hartmann, L Ley… - Journal of …, 2024 - journals.sagepub.com
Background: Research with the Psychedelic Experience Questionnaire/Scale (PES) focuses
on questions relating to mystical experience (Mystical Experience Questionnaire (MEQ)) …

Altered states and social bonds: Effects of MDMA and serotonergic psychedelics on social behavior as a mechanism underlying substance-assisted therapy

Y Schmid, AK Bershad - Biological Psychiatry: Cognitive Neuroscience and …, 2024 - Elsevier
Background There has been renewed interest in the use of 3, 4-methylenedioxy-
methamphetamine (MDMA) and serotonergic psychedelics in the treatment of multiple …

Cardiovascular safety of psychedelic medicine: current status and future directions

A Wsół - Pharmacological Reports, 2023 - Springer
Psychedelics are powerful psychoactive substances that alter perception and mood
processes. Their effectiveness in the treatment of psychiatric diseases was known before …

Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants

P Vizeli, E Studerus, F Holze, Y Schmid… - Translational …, 2024 - nature.com
The pharmacodynamic effects of lysergic acid diethylamide (LSD) are diverse and different
in different individuals. Effects of other psychoactive substances have been shown to be …