IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

One of the major applications of Serum Albumins is their use as delivery systems for
lipophilic compounds in biomedicine. Their biomedical application is based on the similarity …

Introduction A poor pharmacokinetic profile due to inadequate distribution and rapid renal
clearance limits site-specific target engagement and drug efficacy. The inherent properties of …

Macropinocytosis, an evolutionarily conserved endocytic mechanism that mediates non-
specific fluid-phase uptake, is potently upregulated by various oncogenic pathways. It is now …

In this article, we describe a method of delivery of doxorubicin using a novel tumor-homing
peptide-based albumin nanoparticle system to triple-negative breast cancer cells (TNBC) …

Albumin is the most abundant plasma protein, exhibits extended circulating half-life, and its
properties have long been exploited for diagnostics and therapies. Many drugs intrinsically …

Fc-less bispecific T-cell engagers have reached the immuno-oncology market but
necessitate continual infusion due to rapid clearance from the circulation. This work …

Chemotherapy with platinum complexes is essential for clinical anticancer therapy.
However, due to side effects and drug resistance, further drug improvement is urgently …

There is an urgent need to identify new cellular targets to expand the repertoire, potency and
safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a …

Targeted drug delivery approaches that selectively and preferentially deliver therapeutic
agents to specific tissues are of great interest for safer and more effective pharmaceutical …