Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Y Fan, Z Chen, M Zhang - Journal of Translational Medicine, 2022 - Springer
Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease
(AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts …

[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

X Xia, Y Wang, Y Huang, H Zhang, H Lu… - Progress in …, 2019 - Elsevier
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …

MicroRNAs: roles in regulating neuroinflammation

AD Gaudet, LK Fonken, LR Watkins… - The …, 2018 - journals.sagepub.com
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

AM Dickens, LB Tovar-y-Romo, SW Yoo, AL Trout… - Science …, 2017 - science.org
Brain injury induces a peripheral acute cytokine response that directs the transmigration of
leukocytes into the brain. Because this brain-to-peripheral immune communication affects …

Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells

R Lucero, V Zappulli, A Sammarco, OD Murillo… - Cell reports, 2020 - cell.com
Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor
microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM …

A critical systematic review of extracellular vesicle clinical trials

RR Mizenko, M Feaver, BT Bozkurt… - Journal of …, 2024 - Wiley Online Library
This systematic review examines the landscape of extracellular vesicle (EV)‐related clinical
trials to elucidate the field's trends in clinical applications and EV‐related methodologies …

MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis

C Eyileten, Z Wicik, S De Rosa, D Mirowska-Guzel… - Cells, 2018 - mdpi.com
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …

Advanced nanotechnologies for extracellular vesicle‐based liquid biopsy

L Min, B Wang, H Bao, X Li, L Zhao, J Meng… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as a new source of biomarkers in liquid biopsy
because of their wide presence in most body fluids and their ability to load cargoes from …

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury

K Yang, L Zeng, A Ge, S Wang, J Zeng, X Yuan… - Frontiers in …, 2022 - frontiersin.org
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …