Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …

Influenza is a global health concern with millions of infections occurring yearly. Seasonal flu
vaccines are one way to combat this virus; however, they are poorly protective against …

A subunit or protein-based influenza vaccine can be a safer alternative to live attenuated
vaccine (Flumist) and require fewer boosts than an inactivated vaccine (eg Fluzone) …

Better understanding of roles of complement in pathology has fuelled an explosion of
interest in complement-targeted therapeutics. The C5-blocking monoclonal antibody (mAb) …

Complement activation is implicated in driving brain inflammation, self-cell damage and
progression of injury in Alzheimer's disease and other neurodegenerative diseases. Here …

Over the last decade there has been an explosion in complement therapies; one‐third of the
drugs in the clinic or in development target C5 protein. Eculizumab, a monoclonal antibody …

Chlamydia trachomatis (C. trachomatis) is the leading cause of sexually transmitted bacterial
infections worldwide, with over 120 million annual cases. C. trachomatis infections are …

Bullous pemphigoid (BP) is characterized by deposition of immunoglobulins and
complement along the epidermal basement membrane (BM). In humans, there is a lack of …

The implication of complement in multiple diseases over the last 20 years has fuelled
interest in developing anti‐complement drugs. To date, the focus has been on C5; blocking …

Simple Summary Esophageal adenocarcinoma (EAC) is often detected late and has a poor
survival rate. Currently, patients are selected for endoscopy-biopsy diagnosis based on …