The nitrile group is an important functional group widely found in both pharmaceutical
agents and natural products. More than 30 nitrile-containing pharmaceuticals have been …

Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

Context Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing's disease (CD)
when dexamethasone-suppression and CRH tests, and pituitary magnetic resonance …

Cushing syndrome results from supraphysiological exposure to glucocorticoids and is
associated with significant morbidity and mortality. The pathogenesis includes …

Cushing's syndrome is defined by prolonged exposure to glucocorticoids, leading to excess
morbidity and mortality. Diagnosis of this rare pathology is difficult due to the low specificity …

In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for
favorable long-term outcomes, although this remains a challenging task. The differential …

Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary
corticotroph adenoma leads to hypercortisolaemia with high mortality due to metabolic …

Cushing's syndrome (CS) is a rare but detrimental endocrine disorder. Early diagnosis and
prompt treatment are essential since the duration of hypercortisolism has an adverse impact …

Introduction The role of anterior pituitary hormones–ie, adrenocorticotropic hormone
(ACTH), luteinizing and follicle stimulating hormones (LH and FSH), growth hormone (GH) …

Objectives In this systematic review and meta-analysis, we review the literature regarding
patients with Cushing's disease (CD) with negative or inconclusive magnetic resonance …